Daniel C. Sigg, MD, PhD Adjunct Assistant Professor Email: siggx001@umn.edu

Education:
MD University of Basel
PhD Cellular and Integrative Physiology University of Minnesota
Board Certified in Anesthesiology
ECFMG Certification

Current Teaching Activities:
Advanced Cardiac Physiology Short Course
Biotechnology Course

Planned Teaching Activities:
Short course in Cardiac Electrophysiology
Seminar Series on Research in Industry
Mentoring Undergraduate and Graduate Students

Research interests:
Cardiac Electrophysiology / Ion Channels
Ischemia / Reperfusion Injury
Biotechnology Therapies for Arrhythmia and Heart Failure
Effects of Anesthetics on Cardiovascular System
Effects of GLP-1 receptor agonists on CV system
Diabetic cardiomyopathy

Recent Publications:

Greener ID, Monfredi O, Inada S, Chandler NJ, Tellez JO, Atkinson A, Taube MA, Billeter R, Anderson RH, Efimov IR, Molenaar P, Sigg DC, Sharma V, Boyett MR, Dobrzynski H.
Molecular architecture of the human specialised atrioventricular conduction axis.
J Mol Cell Cardiol. 2011 Apr;50(4):642-51.

Xiao YF, Nikolskaya A, Jaye DA, Sigg DC. Glucagon-like peptide-1 enhances cardiac L-type Ca2+ currents via activation of the cAMP-dependent protein kinase A pathway.
Cardiovasc Diabetol. 2011 Jan 20;10:6.

Sill B, Roy N, Hammer PE, Triedman JK, Sigg DC, Kelly MF, Nedder A, Dunning PS, Cowan DB.
Development of an ovine model of pediatric complete heart block.
J Surg Res. 2011 Apr;166(2):e103-8.

Ruhparwar A, Kallenbach K, Klein G, Bara C, Ghodsizad A, Sigg DC, Karck M, Haverich A, Niehaus M. Adenylate-Cyclase VI Transforms Ventricular Cardiomyocytes Into Biological Pacemaker Cells. Tissue Eng Part A. 2010 Jan 12.

Xiao YF, Chandler N, Dobrzynski H, Richardson ES, Tenbroek EM, Wilhelm JJ, Sharma V, Varghese A, Boyett MR, Iaizzo PA, Sigg DC. Hysteresis in human HCN4 channels: A crucial feature potentially affecting sinoatrial node pacemaking.
Acta Physiologica Sinica (Sheng Li Xue Bao). 2010 Feb 25;62(1):1-13.

Ruhparwar A, Kallenbach K, Klein G, Bara C, Ghodsizad A, Sigg DC, Karck M, Haverich A, Niehaus M. Adenylate-Cyclase VI Transforms Ventricular Cardiomyocytes Into Biological Pacemaker Cells.
Tissue Eng Part A. 2010 Jan 12. [Epub ahead of print]

Chandler NJ, Greener ID, Tellez JO, Inada S, Musa H, Molenaar P, Difrancesco D, Baruscotti M, Longhi R, Anderson RH, Billeter R, Sharma V, Sigg DC, Boyett MR, Dobrzynski H. Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker.
Circulation. 2009 Mar 31;119(12):1562-75.

Xiao YF, Sigg DC, Ujhelyi MR, Wilhelm JJ, Richardson ES, Iaizzo PA. Pericardial delivery of omega-3 fatty acid: a novel approach to reducing myocardial infarct sizes and arrhythmias.
Am J Physiol Heart Circ Physiol. 2008 May;294(5):H2212-8.

Xiao YF, Sigg DC. Biological approaches to generating cardiac biopacemaker for bradycardia.
Sheng Li Xue Bao. 2007 Oct 25;59(5):562-70. Review.

Sigg DC, Iaizzo PA. In vivo versus in vitro comparison of swine cardiac performance: induction of cardiodepression with halothane.
Eur J Pharmacol. 2006 Aug 14;543(1-3):97-107.

Viswanathan PC, Coles JA Jr, Sharma V, Sigg DC. Recreating an artificial biological pacemaker: insights from a theoretical model.
Heart Rhythm. 2006 Jul;3(7):824-31.

Sigg DC, Hiniduma-Lokuge P, Coles JA Jr, Falkner P, Rose R, Urban JF, Ujhelyi MR. Focal pharmacological modulation of atrioventricular nodal conduction via implantable catheter: a novel therapy for atrial fibrillation?
Circulation. 2006 May 23;113(20):2383-90.

Xiao YF, TenBroek EM, Wilhelm JJ, Iaizzo PA, Sigg DC. Electrophysiological characterization of murine HL-5 atrial cardiomyocytes.
Am J Physiol Cell Physiol. 2006 Sep;291(3):C407-16.

Varghese A, Tenbroek EM, Coles J Jr, Sigg DC. Endogenous channels in HEK cells and potential roles in HCN ionic current measurements.
Prog Biophys Mol Biol. 2006 Jan-Apr;90(1-3):26-37.

Books
Cardiac Electrophysiology Methods & Models. Editors: Daniel C. Sigg, Paul A. Iaizzo, Yong-Fu Xiao, Bin He. Publisher: Springer. Published 2010. ISBN 9781441966575

Intellectual Property:
Inventor of 5 issued and over 20 pending US patent applications