Daniel C. Sigg, MD, PhD Adjunct Assistant Professor Off campus office address: Novo Nordisk Inc. 1485 Hoyt Ave W St. Paul, MN 55108 Tel. 651-261-2213 Email: siggx001@umn.edu

Education:
MD University of Basel
PhD Cellular and Integrative Physiology University of Minnesota
Board Certified in Anesthesiology
ECFMG Certification

Current Teaching Activities:
Advanced Cardiac Physiology Short Course
Biotechnology Course

Planned Teaching Activities:
Short course in Cardiac Electrophysiology
Seminar Series on Research in Industry
Mentoring Undergraduate and Graduate Students

Research interests:
Cardiac Electrophysiology / Ion Channels
Ischemia / Reperfusion Injury
Biotechnology Therapies for Arrhythmia and Heart Failure
Effects of Anesthetics on Cardiovascular System
Effects of GLP-1 receptor agonists on CV system
Diabetic cardiomyopathy

Recent Publications:

Xiao YF, Sigg DC, Ujhelyi MR, Wilhelm JJ, Richardson ES, Iaizzo PA.
Pericardial delivery of omega-3 fatty acid: a novel approach to reducing myocardial infarct sizes and arrhythmias.
Am J Physiol Heart Circ Physiol. 2008 May;294(5):H2212-8.

Xiao YF, Sigg DC.
Biological approaches to generating cardiac biopacemaker for bradycardia.
Sheng Li Xue Bao. 2007 Oct 25;59(5):562-70. Review.

Sigg DC, Iaizzo PA.
In vivo versus in vitro comparison of swine cardiac performance: induction of cardiodepression with halothane.
Eur J Pharmacol. 2006 Aug 14;543(1-3):97-107.

Viswanathan PC, Coles JA Jr, Sharma V, Sigg DC.
Recreating an artificial biological pacemaker: insights from a theoretical model.
Heart Rhythm. 2006 Jul;3(7):824-31.

Sigg DC, Hiniduma-Lokuge P, Coles JA Jr, Falkner P, Rose R, Urban JF, Ujhelyi MR.
Focal pharmacological modulation of atrioventricular nodal conduction via implantable catheter: a novel therapy for atrial fibrillation?
Circulation. 2006 May 23;113(20):2383-90.

Xiao YF, TenBroek EM, Wilhelm JJ, Iaizzo PA, Sigg DC.
Electrophysiological characterization of murine HL-5 atrial cardiomyocytes.
Am J Physiol Cell Physiol. 2006 Sep;291(3):C407-16.

Varghese A, Tenbroek EM, Coles J Jr, Sigg DC.
Endogenous channels in HEK cells and potential roles in HCN ionic current measurements.
Prog Biophys Mol Biol. 2006 Jan-Apr;90(1-3):26-37.

Intellectual Property:
Inventor of 5 issued and over 20 pending US patent applications