My research interests are in the general area of
solute and water transport across epithelial membranes in the
lung. Epithelial cells in lung airways and alveoli are normally
attached very tightly to one another and provide a substantial
barrier to the movement of solutes and water into or out of the
airspaces of the lung. In lungs injured by disease or external
agents, however, these barriers can become "leaky" and
their transport functions, as well as lung function in general,
may be compromised. We have developed a variety of techniques
to study transport mechanisms in the lung, how those mechanisms
are controlled, the effect of lung injury on epithelial transport
processes, and recovery of those processes following lung injury.
I currently collaborate with colleagues in the Departments of
Medicine and Pediatrics on two studies: stimulation of fluid resorption
across the rat alveolar epithelium and mechanisms of toxin-induced
injury to the airway epithelium.
Guo, Y., M. Krumwiede, J.G. White and O.D. Wangensteen.
(1996) HOCl effects on the tight junctions of rabbit tracheal
epithelium. Am. J. Physiol. 270: L224-L231.
Lasnier, J.M., O.D. Wangensteen, L.S. Schmitz,
C.R. Gross and D.H. Ingbar. (1996) Terbutaline stimulates alveolar
fluid resorption in hyperoxic lung injury. J. Appl. Physiol.
81: 1723-1729.
Wangensteen, O.D., M.M. Bartlett, J.K. James,
Z.-F. Yang and P.S. Low. (1996) Riboflavin-enhanced transport
of serum albumin across the distal pulmonary epithelium. Pharm.
Res. 13: 1861-1864.
Regelmann, W.R., L.A. Schneider, S.C. Fahrenkrug, B.H. Gray,
S. Johnson, J.M. Herron, C.C. Clawson, D.J. Clawson and
O.D. Wangensteen. (1997) Proteinase-free myeloperoxidase
increases airway epithelial permeability in a whole trachea
model. Pediatr. Pulmonology 24: 29-34.
Carter, E.P., O.D. Wangensteen, J. Dunitz
and D.H. Ingbar. (1997) Hyperoxic effects on alveolar sodium
resorption and lung Na,K-ATPase. Am. J. Physiol. 273:
L1191-L1202.
Lasnier, J.M., D.H. Ingbar, E.P. Carter, K. Wilson, S. McKnite,
K.G.Lurie and O.D. Wangensteen. (1998) Perfusion
technique determines alveolar fluid resorption rate in the isolated
perfused rat lung. J. Appl. Physiol. 84: 740-745.
Hotchkiss, J.R., L. Blanch, G. Murias, A.B. Adams, D.A. Olson,
O.D. Wangensteen, P.H. Leo & J.J. Marini.
(2000) Effects of decreased respiratory frequency on ventilator-induced
lung injury. Am. J. Resp. Crit. Care Med. 161: 463-468.
Panoskaltsis-Mortari, A., J.R. Hermanson, E. Taras,
O.D. Wangensteen, I.F. Charo, B.J. Rollins & B.R.
Blazar. (2004) Post-BMT lung injury occurs independently of
the expression of CCL2 or its receptor, CCR2 on host cells.
Am. J. Physiol., Lung Cell Mol. Physiol. 286: L284-L292.
Return
to: Academic Health Center : myAHC : U
of M Home
Last
modified on November 21, 2006