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YEAR 1
| Semester | Course | Credits |
|---|---|---|
| Fall | Cell Physiology PHSL 5700 (or ANSC 5700)
|
4 |
| Molecular biology/genetics course (options below) | 3-5 | |
| Biostatistics (options below) | 3-4 | |
| 1st and 2nd Laboratory Rotations (PHSL 5094) | 2 | |
| IBP seminar series (PHSL 5095) | 1 | |
| Other options are possible depending on prior coursework | ||
| Spring | Medical Physiology PHSL 5101 |
5 |
Systems Physiology Research Topics PHSL 5095 This course for graduate students will include weekly meetings with a graduate faculty member for each system (e.g. CV, respiratory, etc.) which will cover current literature on a selected disease state for that system. This could be a "journal club" format that develops critical thinking skills and reinforces concepts covered in the Cell Physiology course but at the "systems" level. |
1-3 | |
| Bioethics (BTHX 5000, BIOC 8401) | 1-4 | |
| Late Breaking Discoveries in Biomedical Science (PHSL 8220) | 1 | |
| 2nd and 3rd Laboratory Rotation (PHSL 5094) | 2 | |
| Special topics/Seminar series (or PHSL 5095) | 1 | |
| Other options are possible depending on on prior coursework | ||
Written PhD Prelim Exam This exam will be given within 2 weeks of completion of the Spring Semester. It will be essay format testing the ability of the students to apply concepts leraned in the core courses and integrate these concepts into the "big picture". |
||
| Summer | Special topics/Seminar | 1 |
| By the end of summer of Year 1 student must choose laboratory for thesis work. | ||
YEAR 2
| Semester | Course | Credits |
|---|---|---|
| Fall | Supporting program/minor | 3-4 |
| Supporting program/minor | 3-4 | |
| Special topics/Seminar | 1 | |
| Spring | Supporting program/minor | 3-4 |
| Supporting program/minor | 3-4 | |
| Special topics/Seminar | 1 | |
| File thesis Committee Selection/Degree Program with Graduate School | ||
| Schedual Oral Exam with Graduate School | ||
| Write Thesis Proposal in "NIH NRSA" format | ||
Oral PhD Prelim Exam This exam will be based on the Thesis Proposal but the student will be expected to address all and any questions requiring knowledge gained from their coursework. |
||
|
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| Summer | Research | |
| Submit Thesis Proposal Form to Graduate School | ||
| Must have a minimum of 12 Non-PHSL credits accumulated at this point | ||
| Submit Predoctoral Grant Proposal (NIH NRSA or AHA Predoctoral Fellowship) | ||
YEAR 3
| Semester | Course | Credits |
|---|---|---|
| Fall | PHSL 8888 (Thesis Credits) | 12 |
| Spring | PHSL 8888 (Thesis Credits) |
12 |
| Give seminar | ||
YEARS 4 and 5
| Course | Credits | |
|---|---|---|
| PHSL 8444 | 1 | |
| Give Seminar | ||
| Final Thesis Defense no later than end of Year 5 | ||
BIOL 4003 - Genetics
(3.0 cr; =[GCD 3022]; Prereq-[[BIOC 3021 or BIOC 4331], [any CBS major or major in [animal science or applied plant science or BA biology or BA microbiology or nutrition or physiology or biology/society/environment]]] or #; fall, spring, summer, every year)
Introduction to the nature of genetic information, its transmission from parents to offspring, its expression in cells/organisms, and its course in populations.
BIOL 4004 - Cell Biology
(3.0 cr; Prereq-[3021 or BIOC 3021 or BIOC 4331], [4003 or BIOC 4332]; fall, spring, summer, every year)
Processes fundamental to cells. Emphasizes eukaryotic cells. Assembly/function of membranes/organelles. Cell division, cell form/movement, intercellular communication, transport, secretion pathways. Cancer cells, differentiated cells.
BIOC 4331 - Biochemistry I: Structure, Catalysis, and Metabolism in Biological Systems
(4.0 cr; Prereq-[[BIOL 1002 or BIOL 1009 or BIOL 2003 or equiv], [CHEM 2302 or equiv]] or #; fall, spring, every year)
Advanced survey of structure/catalysis, metabolism/bioenergetics.
BIOC 4332 - Biochemistry II: Molecular Mechanisms of Signal Transduction and Gene Expression
(4.0 cr; Prereq-4331 or #; spring, every year)
Advanced survey of molecular biology, mechanisms of gene action, and biological regulation.
* 4000 level courses above only by permission of DGS and advisor
BIOC 5001 - Biochemistry, Molecular and Cellular Biology
(5.0 cr; =[BIOC 6001]; Prereq-undergrad course in biochemistry, #; fall, every year)
Integrated course in biochemistry, molecular biology, cell biology, and developmental biology.
BIOC 6021 - Biochemistry
(3.0 cr; =[BIOC 3021]; Prereq-general biology, organic chemistry, #; intended for MBS students; fall, spring, summer, every year)
Fundamentals of biochemistry. Structure/function of proteins, nucleic acids, lipids and carbohydrates. Metabolism, regulation of metabolism. Quantitative treatments of chemical equilibria, enzyme catalysis, and bioenergetics. Chemical basis of genetic information flow.
GCD 5036 - Molecular Cell Biology
(3.0 cr; Prereq-Biol 4004 or #; [sr or grad student] recommended; fall, every year)
Modern, integrative approaches combining cell/molecular biology, biochemistry, and genetics to investigate cell organization/function. Membranes, signaling, extracellular matrix, secretion, endocytosis, cytoskeleton, nucleus. Analysis of scientific papers to illustrate new concepts in and experimental approaches to cell organization/function.
STAT 5021 - Statistical Analysis
(4.0 cr; =[ANSC 2211, ESPM 3012, STAT 3011]; Prereq-=: 3011; College algebra or #; Stat course recommended; fall, spring, every year)
Intensive introduction to statistical methods for graduate students needing statistics as a research technique.
PUBH 6414 - Biostatistical Methods I
(3.0 cr; =[PUBH 6450]; Prereq-Public Health [MPH or certificate] student or [environmental health [MS or PhD] or health journalism MA or health infomatics [MS or PhD]] major or #; A-F only, fall, spring, summer, offered when feasible)
Descriptive statistics, graphical methods. Use of Excel. Proportions, relative risk, odds ratios. Random sampling. Estimates of mean, medians, measures of variability. Normal distribution, t-/chi-square tests. Confidence intervals. Correlation/regression. Inference/causality.
PUBH 6451 - Biostatistics II
(4.0 cr; Prereq-[[[6420, 6450] or [6414, 6415]] with grade of at least B, health sciences grad student] or #; spring, every year).
Two-way ANOVA, interactions, repeated measures, general linear models. Logistic regression for cohort and case-control studies. Loglinear models, contingency tables, Poisson regression, survival data, Kaplan-Meier methods, proportional hazards models.
BMEN 5001 - Advanced Biomaterials
(3.0 cr; Prereq-3301 or MatS 3011 or grad student or #; A-F or Aud, fall, every year)
Commonly used biomaterials. Chemical/physical aspects. Practical examples from such areas as cardiovascular/orthopedic applications, drug delivery, and cell encapsulation. Methods used for chemical analysis and for physical characterization of biomaterials. Effect of additives, stabilizers, processing conditions, and sterilization methods.
BMEN 5041 - Tissue Engineering
(3.0 cr; Prereq-IT upper div or grad student or med student or #; fall, spring, every year)
Fundamentals of wound healing and tissue repair; characterization of cell-matrix interactions; case study of engineered tissues, including skin, bone marrow, liver, vessel, and cartilage; regulation of biomaterials and engineered tissues.
BMEN 5101 - Advanced Bioelectricity and Instrumentation
(3.0 cr; Prereq-[IT upper div, grad student] or #; spring, offered when feasible)
Instrumentation, computer systems, and processing requirements for clinical physiological signals. Electrode characteristics, signal processing, and interpretation of physiological events by ECG, EEG, and EMG. Measurement of respiration and blood volume/flow.
BMEN 5102 - Bioelectric Measurements and Therapeutic Devices II
(3.0 cr; Prereq-5101 or #; spring, every year)
Theory/application of electrical stimulation in areas of therapeutic/functional neuromuscular stimulation and pain control, cardiac pacing, defibrillation, tissue healing, and electrotherapy. Safety of electric fields. Electrical tissue impedance measurements.
BMEN 5351 - Cell Engineering
(3.0 cr; Prereq-[2501 or 5501], CSCI 1107, [Math 2243 or Math 2373], [IT upper div or grad student or #]; fall, spring, offered when feasible)
Engineering approaches to cell-related phenomena important to cell/tissue engineering. Receptor/ligand binding. Trafficking/signaling processes. Applications to cell proliferation, adhesion, and motility. Cell-matrix interactions.
PHSL 4021 - Advanced Physiology and Bioengineering: Bionic Human
(3.0 cr; Prereq-3061 or 3063 or 5061 or #; A-F only, spring, every year)
"Six million dollar man" theme used to present physiology of different organ systems. Human organs versus advanced synthetic devices. Artificial heart, kidney, lung. Eye versus digital camera. Artificial intelligence of pattern recognition. Web-based course.
PHSL 5095 - Problems in Physiology
(1.0 - 5.0 cr [max 20.0 cr]; Prereq-#; fall, spring, summer, every year)
Individualized study in physiology. Students address selected problem through library or lab research, supervised by physiology faculty.
PHSL 5444 - Muscle
(3.0 cr; =[BIOC 5444]; Prereq-3061 or 3071 or 5061 or BioC 3021 or BioC 4331 or #; spring, every year)
Muscle membranes: structures, mechanisms, and physiological roles of channels/pumps. Muscle contraction: force generation by actin/myosin.
PHSL 5510 - Advanced Cardiac Physiology and Anatomy (Short Course)
(2.0 - 3.0 cr [max 2.0 cr]; Prereq-#; spring, every year) Fundamental concepts, advanced topics related to clinical/biomedical cardiac physiology. Lectures, laboratories, workshops, anatomical dissections. Intense, one week course.
PHSL 5511 - Advanced Neuromuscular Junction Physiology (Short Course)
(2.0 - 3.0 cr [max 2.0 cr]; Prereq-#; summer, every year)
Fundamental concepts and advanced topics related to clinical/biomedical aspects of neuromuscular junction physiology. Lectures, laboratories, workshops, anatomical dissections. Intense, one week course.
PHSL 8222 - Central Regulation of Autonomic Function
(3.0 cr; =[NSC 8222]; Prereq-NSC 5561 or #; A-F or Aud)
Neural/hormonal sensory pathways affecting central autonomic nuclei involved in maintenance of homeostasis. Current research on physiological control systems at cellular, organ, and integrative levels. Offered fall of odd-numbered years.
PHSL 8310 - Advanced Topics in Cellular Physiology
(1.0 cr [max 4.0 cr]; Prereq-#; fall, spring, every year)
Discussion of primary research publications. Topics vary by semester
“Designer” pharmacology course (Katz has details) 2-3 credits
GCD 4134 - Endocrinology
(3.0 cr; Prereq-Biol 3211 or Biol/BioC 3021 or BioC 4331 or #)
Survey of structure and function of invertebrate and vertebrate endocrine systems.
PHCL 8110 - Advanced Pharmacology
(4.0 cr; Prereq-5110 or #; A-F or Aud, spring, every year)
Contemporary research concepts, experimental approaches in investigative pharmacology. Mechanisms of action of drugs on systems (whole animal), organ, and cellular levels.
PHCL 8216 - Signal Transduction and Gene Expression
(3.0 cr; =[01540]; Prereq-BIOC 8002 or #; spring, every year)
Mechanisms of intracellular signal transduction. Transcriptional regulation. Cellular/molecular techniques to study cell signaling. Well-characterized signaling pathways, Experimental approaches. Current issues/problems.
CMB 8344 - Mechanisms of Hormone Action
(2.0 cr; Prereq-Course in biochemistry or cell biology or #; fall, even years)
Mechanisms of hormone/cytokine action. Focuses on major signal transduction/apoptosis. Topics incorporate pharmacology, biochemistry, and cell biology of hormone action in relevant physiological systems. Lectures on basic principles. Specialized lectures. Discussion of primary literature.
NSC 5540 - Advanced Survey of Biomedical Neuroscience (Short Course)
(2.0 cr; Prereq-#; intended for members of biomedical community or students with advanced scientific backgrounds; summer, every year)
Current topics in biomedical neuroscience, accompanied by supporting, fundamental concepts. Intensive, one week course.