Physiology
of Drug Absorption, Distribution and Elimination:
Individual
and Population-based Approaches
(PHSL 5530)
NEXT
OFFERED: June 11-15, 2007 (pending sufficient enrollment)
Instructors:
. David G. Levitt, M.D., Ph.D. (Course
Director)
E-mail: levit001@umn.edu
Dr. Levitt is a professor in the Department of Physiology at the University of
Minnesota Medical School and is the developer of PKQuest.
. Richard
Brundage, Pharm.D., Ph.D.
E-mail: brund001@umn.edu
Dr.
Brundage is an associate professor in the College of Pharmacy
and Director of Graduate Studies for Experimental and Clinical
Pharmacology. His research
is focused on the evaluation of the clinical pharmacokinetics and pharmacodynamics
of antiviral agents primarily targeted against HIV and the application
of population pharmacokinetics and nonlinear mixed effects
modeling to analysis and interpretation
of pharmacokinetic data. He has extensive experience in the use of NONMEM and
has been a workshop instructor at the NONMEM Project Group short courses.
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The first 3 days cover the major approaches used in individual
pharmacokinetics:
-
general non-compartmental pharmacokinetic relationships
- compartmental pharmacokinetics
- deconvolution based
analysis
- physiologically based pharmacokinetic modeling
Lecture
topics: clearance, volume of distribution, capillary permeability,
blood flow limitation, first pass metabolism,
bioavailability, models
of liver metabolism, renal excretion, blood-brain barrier,
octanol partition coefficients, protein binding, volatile
solutes, intestinal
absorption,
skin absorption, peptide transport system. ABC transport
system. This set of lectures
and workshops will be based on the use of
PKQuest -
a new, general, pharmacokinetic software routine,
developed by David Levitt. Each
participant will be expected to have a laptop
computer on which they will work lecture examples and carry out
the detailed pharmacokinetic analysis in the workshop sessions. (AC outlets will be available for each participant).
The last 2 days cover population pharmacokinetics
and the use of the NONMEM software package.
- fixed effects
- random effects
- interindividual
variability
- residual variability
- mixed-effects
modeling
The format for
this section consists of lectures and structured, hands-on workshops,
with an emphasis on using
NONMEM for population pharmacokinetics. Lectures will present
fundamental principles
of population analyses, and these will be followed
by computer-based examples. Participants will use
existing workstation
installations
of NONMEM and will not be required to obtain
individual licenses.
On completion of
this course, participants should have all the information and tools
necessary to perform state of the art pharmacokinetic
analysis on their own data.
Hardware and software
requirements:
- Laptop computer
(preferably PC, but Macintosh should be acceptable).
- Maple
(Waterloo, Inc) software package version 8 or later. (Version 9 required
for Macintosh). This must be purchased (student
price $100) and installed before attending the workshop
- PKQuest pharmacokinetic
software. This is freely distributed and should be downloaded
and installed before attending the
workshop. Maple is required for the use of PKQuest.
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